The study was published in the journal of the European Association for the Study of Diabetes called Diabetologia.
Researchers found that the use of statins was linked with a 46% increased risk of developing diabetes.
Previous studies have shown that patients who use statins risk developing diabetes, but these studies were mostly based on the fasting glucose measurement of the patients. This made the researchers underestimate the actual numbers of diabetes cases.
The new study, conducted by Markku Laakso, professor at the Institute of Clinical Medicine, and analyzed the effects statin treatment has on type 2 diabetes and its effects on the deterioration of blood sugar control.
The study followed 8,749 men who did not have diabetes over the course of 6 years. The researchers investigated how statins induced diabetes by studying changes in the insulin secretion and insulin resistance.
Those who participated in the study were men of ages between 45 and 73, and scientists followed them for approximately 5 years.
625 of the men were diagnosed with diabetes using a glucose tolerance test taken orally, an HbA1c level of 6.5 per cent or higher. Also, the scientists evaluated the anti-diabetic treatments the patients took, and the insulin secretion and sensitivity of the participants.
The researchers adjusted the results according to the participants’ age, body mass index, physical activity, alcohol and smoking habits, any history of diabetes in the family, any diuretic or beta-blocker treatments.
After all this, the study revealed that patients who took statins were more likely to develop diabetes by 46%, compared to the participants who did not use statins.
According to the researchers, statins increased 2-h glucose and the fasting glucose.
Also, those who underwent statin treatment had a decreased sensitivity to insulin by 24% and their insulin secretion went down by 12%.
The authors of the study commented that the association of statin treatment with an increased risk of developing diabetes is because statins decrease the levels of insulin secretion and sensitivity.
Image Source: walesonline